The three major U.S. stock indexes opened mixed, with the Dow opening down 0.24%, the S&P 500 opening up 0.23%, and the Nasdaq opening up 0.29%. Cryptocurrency concept stocks opened lower, MicroStrategy (MSTR.O) fell 5.9%, Coinbase (COIN.O) fell 3.9 per cent, Riot Blockchain (RIOT.O) fell 5.1%.