According to ChainCatcher, citing Golden Ten Data, the Dow Jones Industrial Average closed down 334.33 points, or 0.71%, at 46,590.41 points on Wednesday, October 22. The S&P 500 Index closed down 35.93 points, or 0.53%, at 6,699.42 points. The Nasdaq Composite Index closed down 213.27 points, or 0.93%, at 22,740.4 points.